Drug interactions
Clonazepam + Levetiracetam
Severity: Minor
Clonazepam and Levetiracetam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence, dizziness and coordination problems, so the combination may increase these effects. They are frequently combined in epilepsy treatment and are generally tolerated.
What this interaction means in plain words
Clonazepam and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clonazepam belongs to Central Nervous System; Levetiracetam belongs to Central Nervous System.
Why it happens
Additive CNS depression; there is no significant pharmacokinetic interaction.
What to do
Monitor for drowsiness and dizziness when starting or increasing either drug. Counsel on driving until the response is known.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Levetiracetam
Frequently asked questions
Can I take Clonazepam with Levetiracetam?
MediHelp rates the interaction as minor. Clonazepam and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause somnolence, dizziness and coordination problems, so the combination may increase these effects. They are frequently combined in epilepsy treatment and are generally tolerated.
How serious is the interaction between Clonazepam and Levetiracetam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and dizziness when starting or increasing either drug. Counsel on driving until the response is known.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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