Drug interactions
Clonazepam + Loxapine
Severity: Major
Clonazepam and Loxapine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine is sedating, and with clonazepam the effect on alertness and coordination is additive. Inhaled loxapine has a warning about bronchospasm and respiratory effects, and benzodiazepines may compound respiratory depression.
What this interaction means in plain words
Clonazepam and Loxapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clonazepam belongs to Central Nervous System; Loxapine belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression from GABA-A potentiation and loxapine receptor blockade.
What to do
Monitor sedation and respiration, using lower doses where possible. For inhaled loxapine, observe closely for respiratory compromise and follow labeling precautions.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Clonazepam with Loxapine?
MediHelp rates the interaction as major. Clonazepam and Loxapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Loxapine is sedating, and with clonazepam the effect on alertness and coordination is additive. Inhaled loxapine has a warning about bronchospasm and respiratory effects, and benzodiazepines may compound respiratory depression.
How serious is the interaction between Clonazepam and Loxapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiration, using lower doses where possible. For inhaled loxapine, observe closely for respiratory compromise and follow labeling precautions.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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