Drug interactions
Clonazepam + Maprotiline
Severity: Moderate
Clonazepam and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline is a sedating antidepressant, and with clonazepam it can lead to additive drowsiness and psychomotor impairment. Overdose is more hazardous, and maprotiline also lowers seizure threshold, which may partly oppose the anticonvulsant effect of clonazepam.
What this interaction means in plain words
Clonazepam and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and antihistaminic effects; maprotiline lowers the seizure threshold.
What to do
Monitor sedation and, in epilepsy patients, seizure control. Use the lowest effective maprotiline dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Clonazepam with Maprotiline?
MediHelp rates the interaction as moderate. Clonazepam and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline is a sedating antidepressant, and with clonazepam it can lead to additive drowsiness and psychomotor impairment. Overdose is more hazardous, and maprotiline also lowers seizure threshold, which may partly oppose the anticonvulsant effect of clonazepam.
How serious is the interaction between Clonazepam and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and, in epilepsy patients, seizure control. Use the lowest effective maprotiline dose.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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