Drug interactions
Clonazepam + Metaxalone
Severity: Moderate
Clonazepam and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clonazepam adds to the sedative effect of metaxalone, increasing the risk of drowsiness, impaired coordination and falls. Respiratory depression is a concern at higher doses or in vulnerable patients.
What this interaction means in plain words
Clonazepam and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depression via GABA-A potentiation and metaxalone's sedative effect.
What to do
Use the lowest effective doses for the shortest duration and monitor for oversedation. Avoid alcohol and counsel on driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Frequently asked questions
Can I take Clonazepam with Metaxalone?
MediHelp rates the interaction as moderate. Clonazepam and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clonazepam adds to the sedative effect of metaxalone, increasing the risk of drowsiness, impaired coordination and falls. Respiratory depression is a concern at higher doses or in vulnerable patients.
How serious is the interaction between Clonazepam and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and monitor for oversedation. Avoid alcohol and counsel on driving.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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