Drug interactions
Clonazepam + Methohexital
Severity: Moderate
Clonazepam and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a barbiturate anesthetic and adds to the CNS and respiratory depression of benzodiazepines. Deeper sedation and hypoventilation may occur.
What this interaction means in plain words
Clonazepam and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depression from barbiturate and benzodiazepine potentiation of GABA-A receptors.
What to do
Give methohexital only by experienced personnel with airway and ventilation monitoring, and titrate to effect with a reduced dose. Inform the anesthesia team of regular clonazepam use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Methohexital
Frequently asked questions
Can I take Clonazepam with Methohexital?
MediHelp rates the interaction as moderate. Clonazepam and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a barbiturate anesthetic and adds to the CNS and respiratory depression of benzodiazepines. Deeper sedation and hypoventilation may occur.
How serious is the interaction between Clonazepam and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give methohexital only by experienced personnel with airway and ventilation monitoring, and titrate to effect with a reduced dose. Inform the anesthesia team of regular clonazepam use.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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