Drug interactions
Clonazepam + Mifepristone
Severity: Moderate
Clonazepam and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may raise clonazepam concentrations, increasing sedation, psychomotor impairment and respiratory depression. The effect is likely most relevant with prolonged mifepristone exposure, such as in Cushing syndrome treatment.
What this interaction means in plain words
Clonazepam and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Mifepristone belongs to Endocrine.
Why it happens
Mifepristone inhibits CYP3A4, reducing clonazepam metabolism.
What to do
Monitor for excess sedation and consider lowering the clonazepam dose when mifepristone is given long term. Counsel the patient about impaired driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Clonazepam with Mifepristone?
MediHelp rates the interaction as moderate. Clonazepam and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may raise clonazepam concentrations, increasing sedation, psychomotor impairment and respiratory depression. The effect is likely most relevant with prolonged mifepristone exposure, such as in Cushing syndrome treatment.
How serious is the interaction between Clonazepam and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and consider lowering the clonazepam dose when mifepristone is given long term. Counsel the patient about impaired driving.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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