Drug interactions
Clonazepam + Teduglutide
Severity: Moderate
Clonazepam and Teduglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teduglutide improves intestinal fluid and nutrient absorption and may increase absorption of oral drugs such as clonazepam. This could raise clonazepam levels and sedation in some patients, though the effect is not well quantified.
What this interaction means in plain words
Clonazepam and Teduglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Teduglutide belongs to Endocrine.
Why it happens
Enhanced intestinal absorption of oral medications due to teduglutide's intestinotrophic effects.
What to do
Monitor for increased sedation or reduced seizure threshold changes when teduglutide is started, and adjust clonazepam dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Teduglutide
- Chlordiazepoxide + Teduglutide Moderate
- Colchicine + Teduglutide Moderate
- Cyclosporin + Teduglutide Moderate
- Digoxin + Teduglutide Moderate
- Ethosuximide + Teduglutide Moderate
- Flecainide + Teduglutide Moderate
Frequently asked questions
Can I take Clonazepam with Teduglutide?
MediHelp rates the interaction as moderate. Clonazepam and Teduglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teduglutide improves intestinal fluid and nutrient absorption and may increase absorption of oral drugs such as clonazepam. This could raise clonazepam levels and sedation in some patients, though the effect is not well quantified.
How serious is the interaction between Clonazepam and Teduglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation or reduced seizure threshold changes when teduglutide is started, and adjust clonazepam dose as needed.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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