Drug interactions
Digoxin + Teduglutide
Severity: Moderate
Digoxin and Teduglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teduglutide improves intestinal fluid and nutrient absorption and may increase absorption of oral drugs. For a narrow therapeutic index drug like digoxin, this could raise exposure.
What this interaction means in plain words
Digoxin and Teduglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Teduglutide belongs to Endocrine.
Why it happens
Enhanced intestinal absorptive capacity may increase oral digoxin absorption.
What to do
Monitor digoxin concentrations and signs of toxicity when starting teduglutide, and reduce the digoxin dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Teduglutide
- Chlordiazepoxide + Teduglutide Moderate
- Clonazepam + Teduglutide Moderate
- Colchicine + Teduglutide Moderate
- Cyclosporin + Teduglutide Moderate
- Ethosuximide + Teduglutide Moderate
- Flecainide + Teduglutide Moderate
Frequently asked questions
Can I take Digoxin with Teduglutide?
MediHelp rates the interaction as moderate. Digoxin and Teduglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teduglutide improves intestinal fluid and nutrient absorption and may increase absorption of oral drugs. For a narrow therapeutic index drug like digoxin, this could raise exposure.
How serious is the interaction between Digoxin and Teduglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentrations and signs of toxicity when starting teduglutide, and reduce the digoxin dose if needed.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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