Drug interactions
Clonazepam + Ziprasidone
Severity: Moderate
Clonazepam and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation, so combined use can increase drowsiness, dizziness and impaired alertness. Orthostatic hypotension and falls may also be more likely, especially in older or frail patients.
What this interaction means in plain words
Clonazepam and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from benzodiazepine GABA-A enhancement and the antihistaminic and antiadrenergic effects of ziprasidone.
What to do
Use the lowest effective benzodiazepine dose and monitor for oversedation and orthostatic symptoms, especially after initiation or titration. Counsel patients on driving and fall precautions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Clonazepam with Ziprasidone?
MediHelp rates the interaction as moderate. Clonazepam and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation, so combined use can increase drowsiness, dizziness and impaired alertness. Orthostatic hypotension and falls may also be more likely, especially in older or frail patients.
How serious is the interaction between Clonazepam and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective benzodiazepine dose and monitor for oversedation and orthostatic symptoms, especially after initiation or titration. Counsel patients on driving and fall precautions.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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