Drug interactions
Clonidine + Eluxadoline
Severity: Minor
Clonidine and Eluxadoline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline is a weak inhibitor of CYP3A4 and may slightly raise levels of CYP3A substrates. Clonidine is not primarily cleared by CYP3A4, so a clinically meaningful effect is unlikely.
What this interaction means in plain words
Clonidine and Eluxadoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clonidine belongs to Cardiovascular; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
Weak CYP3A4 inhibition by eluxadoline, which has limited relevance for clonidine clearance.
What to do
No dose change is needed. Monitor blood pressure and heart rate if symptoms of excess clonidine effect appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Clonidine with Eluxadoline?
MediHelp rates the interaction as minor. Clonidine and Eluxadoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eluxadoline is a weak inhibitor of CYP3A4 and may slightly raise levels of CYP3A substrates. Clonidine is not primarily cleared by CYP3A4, so a clinically meaningful effect is unlikely.
How serious is the interaction between Clonidine and Eluxadoline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor blood pressure and heart rate if symptoms of excess clonidine effect appear.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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