Drug interactions
Clonidine + Flibanserin
Severity: Moderate
Clonidine and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin can inhibit P-glycoprotein, which might raise exposure of some substrates. Clonidine is not a clearly established clinically significant P-gp substrate, but both drugs lower blood pressure and cause sedation, so additive hypotension, bradycardia and drowsiness are the main concern.
What this interaction means in plain words
Clonidine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Flibanserin belongs to Genitourinary.
Why it happens
Additive hypotensive and sedative effects; possible minor P-gp inhibition by flibanserin.
What to do
Monitor blood pressure, heart rate and sedation. Counsel the patient about orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clonidine and Flibanserin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Clonidine with Flibanserin?
MediHelp rates the interaction as moderate. Clonidine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flibanserin can inhibit P-glycoprotein, which might raise exposure of some substrates. Clonidine is not a clearly established clinically significant P-gp substrate, but both drugs lower blood pressure and cause sedation, so additive hypotension, bradycardia and drowsiness are the main concern.
How serious is the interaction between Clonidine and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and sedation. Counsel the patient about orthostatic symptoms.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
