Drug interactions
Clonidine + Fluphenazine
Severity: Moderate
Clonidine and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine has alpha-1 blocking and sedative effects that can add to the hypotensive and sedative actions of clonidine. Patients may experience orthostatic hypotension, dizziness and falls.
What this interaction means in plain words
Clonidine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive hypotensive and CNS depressant effects.
What to do
Monitor supine and standing blood pressure and sedation after starting or adjusting either drug. Reduce the dose of one agent if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Clonidine with Fluphenazine?
MediHelp rates the interaction as moderate. Clonidine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine has alpha-1 blocking and sedative effects that can add to the hypotensive and sedative actions of clonidine. Patients may experience orthostatic hypotension, dizziness and falls.
How serious is the interaction between Clonidine and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure and sedation after starting or adjusting either drug. Reduce the dose of one agent if symptomatic hypotension occurs.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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