Drug interactions
Clonidine + Haloperidol
Severity: Moderate
Clonidine and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clonidine and haloperidol can both lower blood pressure and cause sedation, which may lead to dizziness and orthostatic hypotension. Clonidine's bradycardic effect together with haloperidol's QT-prolonging potential, especially at high intravenous doses, may increase arrhythmia risk.
What this interaction means in plain words
Clonidine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Haloperidol belongs to Central Nervous System.
Why it happens
Additive hypotensive and sedative effects, with bradycardia from clonidine compounding haloperidol-related QT prolongation.
What to do
Monitor blood pressure and heart rate, and obtain an ECG when haloperidol is given at high or intravenous doses. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Clonidine with Haloperidol?
MediHelp rates the interaction as moderate. Clonidine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clonidine and haloperidol can both lower blood pressure and cause sedation, which may lead to dizziness and orthostatic hypotension. Clonidine's bradycardic effect together with haloperidol's QT-prolonging potential, especially at high intravenous doses, may increase arrhythmia risk.
How serious is the interaction between Clonidine and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and obtain an ECG when haloperidol is given at high or intravenous doses. Correct potassium and magnesium abnormalities.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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