Drug interactions
Clonidine + Ivabradine
Severity: Moderate
Clonidine and Ivabradine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower heart rate, so combined use raises the risk of symptomatic bradycardia, dizziness and conduction disturbance. Abrupt clonidine withdrawal may also cause rebound tachycardia and hypertension.
What this interaction means in plain words
Clonidine and Ivabradine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Ivabradine belongs to Cardiovascular.
Why it happens
Additive heart rate lowering from central sympatholysis by clonidine and sinus node If-current inhibition by ivabradine.
What to do
Monitor heart rate and ECG, and reduce or stop ivabradine if resting heart rate falls too low or symptoms occur. Taper clonidine gradually if it must be stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Frequently asked questions
Can I take Clonidine with Ivabradine?
MediHelp rates the interaction as moderate. Clonidine and Ivabradine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower heart rate, so combined use raises the risk of symptomatic bradycardia, dizziness and conduction disturbance. Abrupt clonidine withdrawal may also cause rebound tachycardia and hypertension.
How serious is the interaction between Clonidine and Ivabradine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG, and reduce or stop ivabradine if resting heart rate falls too low or symptoms occur. Taper clonidine gradually if it must be stopped.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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