Drug interactions
Clonidine + Lasmiditan
Severity: Moderate
Clonidine and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan commonly causes dizziness and sedation, and clonidine adds drowsiness and may lower blood pressure. The combination may increase impairment of alertness and driving ability.
What this interaction means in plain words
Clonidine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects of lasmiditan and clonidine.
What to do
Advise patients not to drive for at least 8 hours after lasmiditan. Monitor for excessive sedation and dizziness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Clonidine with Lasmiditan?
MediHelp rates the interaction as moderate. Clonidine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan commonly causes dizziness and sedation, and clonidine adds drowsiness and may lower blood pressure. The combination may increase impairment of alertness and driving ability.
How serious is the interaction between Clonidine and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients not to drive for at least 8 hours after lasmiditan. Monitor for excessive sedation and dizziness.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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