Drug interactions
Clonidine + Levomilnacipran
Severity: Moderate
Clonidine and Levomilnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levomilnacipran inhibits norepinephrine reuptake and can raise blood pressure and heart rate, potentially offsetting the antihypertensive effect of clonidine. Rebound or erratic blood pressure may result, especially with variable adherence.
What this interaction means in plain words
Clonidine and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Levomilnacipran belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between norepinephrine reuptake inhibition and central alpha-2 mediated sympathetic suppression.
What to do
Monitor blood pressure after starting or changing levomilnacipran and adjust antihypertensive therapy as needed. Do not stop clonidine abruptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Clonidine with Levomilnacipran?
MediHelp rates the interaction as moderate. Clonidine and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levomilnacipran inhibits norepinephrine reuptake and can raise blood pressure and heart rate, potentially offsetting the antihypertensive effect of clonidine. Rebound or erratic blood pressure may result, especially with variable adherence.
How serious is the interaction between Clonidine and Levomilnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or changing levomilnacipran and adjust antihypertensive therapy as needed. Do not stop clonidine abruptly.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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