Drug interactions
Levomilnacipran + Rasagiline
Severity: Contraindicated
Levomilnacipran and Rasagiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levomilnacipran with an MAO inhibitor can cause serotonin syndrome and hypertensive reactions. Labeling contraindicates concurrent use and use within 14 days of stopping an MAO inhibitor.
What this interaction means in plain words
Levomilnacipran and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levomilnacipran belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Why it happens
Serotonin and norepinephrine reuptake inhibition combined with blocked monoamine breakdown results in excess synaptic monoamines.
What to do
Do not co-administer and keep a 14-day washout between the two drugs. Choose another antidepressant when an MAO-B inhibitor is needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Safinamide Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Rasagiline?
MediHelp rates the interaction as contraindicated. Levomilnacipran and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levomilnacipran with an MAO inhibitor can cause serotonin syndrome and hypertensive reactions. Labeling contraindicates concurrent use and use within 14 days of stopping an MAO inhibitor.
How serious is the interaction between Levomilnacipran and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer and keep a 14-day washout between the two drugs. Choose another antidepressant when an MAO-B inhibitor is needed.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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