Drug interactions
Levomilnacipran + Procarbazine
Severity: Contraindicated
Levomilnacipran and Procarbazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levomilnacipran is a serotonin and noradrenaline reuptake inhibitor, and procarbazine has MAO inhibitor activity. The combination can result in serotonin syndrome or hypertensive crisis, which may be fatal.
What this interaction means in plain words
Levomilnacipran and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levomilnacipran belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
Combined MAO inhibition and serotonin-noradrenaline reuptake inhibition produces excessive monoamine accumulation.
What to do
Do not combine. Allow at least 14 days after stopping procarbazine before starting levomilnacipran, and at least 7 days after stopping levomilnacipran before starting procarbazine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
- Levomilnacipran + Safinamide Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Procarbazine?
MediHelp rates the interaction as contraindicated. Levomilnacipran and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levomilnacipran is a serotonin and noradrenaline reuptake inhibitor, and procarbazine has MAO inhibitor activity. The combination can result in serotonin syndrome or hypertensive crisis, which may be fatal.
How serious is the interaction between Levomilnacipran and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Allow at least 14 days after stopping procarbazine before starting levomilnacipran, and at least 7 days after stopping levomilnacipran before starting procarbazine.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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