Drug interactions
Levomilnacipran + Linezolid
Severity: Contraindicated
Levomilnacipran and Linezolid: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levomilnacipran inhibits serotonin and norepinephrine reuptake, while linezolid inhibits MAO. The combination can cause serotonin syndrome, and its labeling contraindicates concurrent use with MAOIs including linezolid.
What this interaction means in plain words
Levomilnacipran and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levomilnacipran belongs to Central Nervous System; Linezolid belongs to Anti Bacterial.
Why it happens
Additive serotonergic effects from reuptake inhibition plus reduced monoamine metabolism by MAO inhibition.
What to do
Avoid the combination and stop levomilnacipran before linezolid, restarting it 24 hours after the last linezolid dose. In urgent situations, stop levomilnacipran and monitor for serotonin syndrome for about two weeks or until 24 hours after the last linezolid dose.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
- Levomilnacipran + Safinamide Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Linezolid?
MediHelp rates the interaction as contraindicated. Levomilnacipran and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levomilnacipran inhibits serotonin and norepinephrine reuptake, while linezolid inhibits MAO. The combination can cause serotonin syndrome, and its labeling contraindicates concurrent use with MAOIs including linezolid.
How serious is the interaction between Levomilnacipran and Linezolid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and stop levomilnacipran before linezolid, restarting it 24 hours after the last linezolid dose. In urgent situations, stop levomilnacipran and monitor for serotonin syndrome for about two weeks or until 24 hours after the last linezolid dose.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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