Drug interactions
Clonidine + Macimorelin
Severity: Moderate
Clonidine and Macimorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clonidine stimulates growth hormone release and may alter the result of the macimorelin growth hormone stimulation test. This could lead to a false interpretation of growth hormone status.
What this interaction means in plain words
Clonidine and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Macimorelin belongs to Endocrine.
Why it happens
Clonidine transiently raises growth hormone secretion through alpha-2 adrenergic stimulation, confounding the diagnostic response.
What to do
Hold clonidine for an adequate washout period before macimorelin testing when it is clinically safe, and monitor blood pressure while it is held.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Macimorelin
Frequently asked questions
Can I take Clonidine with Macimorelin?
MediHelp rates the interaction as moderate. Clonidine and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clonidine stimulates growth hormone release and may alter the result of the macimorelin growth hormone stimulation test. This could lead to a false interpretation of growth hormone status.
How serious is the interaction between Clonidine and Macimorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold clonidine for an adequate washout period before macimorelin testing when it is clinically safe, and monitor blood pressure while it is held.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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