Drug interactions
Clonidine + Midazolam
Severity: Moderate
Clonidine and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clonidine has sedative and hypotensive properties that add to midazolam sedation. Together they may cause deeper sedation, bradycardia and hypotension.
What this interaction means in plain words
Clonidine and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Midazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression and sympatholytic effects via central alpha-2 agonism plus GABA-A potentiation.
What to do
Reduce midazolam dose as needed and monitor sedation, heart rate, blood pressure and oxygen saturation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Clonidine with Midazolam?
MediHelp rates the interaction as moderate. Clonidine and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clonidine has sedative and hypotensive properties that add to midazolam sedation. Together they may cause deeper sedation, bradycardia and hypotension.
How serious is the interaction between Clonidine and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce midazolam dose as needed and monitor sedation, heart rate, blood pressure and oxygen saturation.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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