Drug interactions
Clonidine + Perphenazine
Severity: Moderate
Clonidine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower blood pressure and cause sedation, so combined use may cause additive orthostatic hypotension and drowsiness. Perphenazine is also a CYP2D6 substrate but this is not relevant to clonidine.
What this interaction means in plain words
Clonidine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Perphenazine belongs to Central Nervous System.
Why it happens
Additive hypotensive and sedative effects from central alpha-2 agonism and phenothiazine alpha-1 blockade and CNS depression.
What to do
Monitor blood pressure, including orthostatic readings, and sedation when starting or adjusting doses. Reduce one agent if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Clonidine with Perphenazine?
MediHelp rates the interaction as moderate. Clonidine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower blood pressure and cause sedation, so combined use may cause additive orthostatic hypotension and drowsiness. Perphenazine is also a CYP2D6 substrate but this is not relevant to clonidine.
How serious is the interaction between Clonidine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including orthostatic readings, and sedation when starting or adjusting doses. Reduce one agent if symptomatic.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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