Drug interactions
Clonidine + Ribociclib
Severity: Minor
Clonidine and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 and can raise levels of CYP3A4 substrates, but clonidine is only partly metabolised this way. Mild increases in hypotension or bradycardia are possible, and ribociclib also prolongs the QT interval.
What this interaction means in plain words
Clonidine and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clonidine belongs to Cardiovascular; Ribociclib belongs to Oncology.
Why it happens
CYP3A4 inhibition by ribociclib may modestly reduce clonidine clearance.
What to do
Monitor blood pressure and heart rate when the combination is started. Adjust the clonidine dose only if symptomatic bradycardia or hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Clonidine with Ribociclib?
MediHelp rates the interaction as minor. Clonidine and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib inhibits CYP3A4 and can raise levels of CYP3A4 substrates, but clonidine is only partly metabolised this way. Mild increases in hypotension or bradycardia are possible, and ribociclib also prolongs the QT interval.
How serious is the interaction between Clonidine and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when the combination is started. Adjust the clonidine dose only if symptomatic bradycardia or hypotension develops.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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