Drug interactions
Clonidine + Sarilumab
Severity: Minor
Clonidine and Sarilumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
IL-6 blockade can reverse cytokine-mediated suppression of CYP enzymes, potentially lowering levels of drugs metabolized by them. Clonidine is only partly CYP-metabolized (including CYP2D6) and has a wide margin, so any effect is likely small.
What this interaction means in plain words
Clonidine and Sarilumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clonidine belongs to Cardiovascular; Sarilumab belongs to Musculoskeletal.
Why it happens
Sarilumab may normalize IL-6-suppressed CYP450 activity, possibly increasing clearance of CYP substrates.
What to do
No routine adjustment is needed; monitor blood pressure when sarilumab is started or stopped and adjust clonidine if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Sarilumab
Frequently asked questions
Can I take Clonidine with Sarilumab?
MediHelp rates the interaction as minor. Clonidine and Sarilumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. IL-6 blockade can reverse cytokine-mediated suppression of CYP enzymes, potentially lowering levels of drugs metabolized by them. Clonidine is only partly CYP-metabolized (including CYP2D6) and has a wide margin, so any effect is likely small.
How serious is the interaction between Clonidine and Sarilumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood pressure when sarilumab is started or stopped and adjust clonidine if control changes.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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