Drug interactions
Clonidine + Temazepam
Severity: Moderate
Clonidine and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clonidine and temazepam both cause sedation, and clonidine can also lower blood pressure. Together they may increase drowsiness, dizziness, impaired psychomotor performance and fall risk, especially in older patients.
What this interaction means in plain words
Clonidine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Temazepam belongs to Central Nervous System.
Why it happens
Additive central nervous system depression via central alpha-2 agonism and GABA-A potentiation.
What to do
Use the lowest effective temazepam dose and monitor for oversedation and orthostatic hypotension. Advise avoiding alcohol and driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Clonidine with Temazepam?
MediHelp rates the interaction as moderate. Clonidine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clonidine and temazepam both cause sedation, and clonidine can also lower blood pressure. Together they may increase drowsiness, dizziness, impaired psychomotor performance and fall risk, especially in older patients.
How serious is the interaction between Clonidine and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective temazepam dose and monitor for oversedation and orthostatic hypotension. Advise avoiding alcohol and driving until the response is known.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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