Drug interactions
Clopidogrel + Cyclosporin
Severity: Moderate
Clopidogrel and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may reduce formation of the active metabolite of clopidogrel, potentially weakening platelet inhibition. The clinical relevance is uncertain and cyclosporine also inhibits P-glycoprotein and OATP transporters.
What this interaction means in plain words
Clopidogrel and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Cyclosporin belongs to Miscellaneous.
Why it happens
Cyclosporine inhibits CYP3A4, which is one of the enzymes involved in clopidogrel bioactivation.
What to do
Monitor for thrombotic events in high-risk patients and consider platelet function testing or an alternative antiplatelet drug if reduced efficacy is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Cyclosporin?
MediHelp rates the interaction as moderate. Clopidogrel and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may reduce formation of the active metabolite of clopidogrel, potentially weakening platelet inhibition. The clinical relevance is uncertain and cyclosporine also inhibits P-glycoprotein and OATP transporters.
How serious is the interaction between Clopidogrel and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for thrombotic events in high-risk patients and consider platelet function testing or an alternative antiplatelet drug if reduced efficacy is a concern.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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