Drug interactions
Clopidogrel + Desvenlafaxine
Severity: Moderate
Clopidogrel and Desvenlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SNRIs impair platelet serotonin uptake and increase bleeding tendency, especially GI bleeding, when taken with antiplatelet drugs like clopidogrel.
What this interaction means in plain words
Clopidogrel and Desvenlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Desvenlafaxine belongs to Central Nervous System.
Why it happens
Additive effect on platelet aggregation via reduced platelet serotonin plus P2Y12 inhibition.
What to do
Monitor for bleeding and consider gastroprotection in patients with additional risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clopidogrel
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Clopidogrel with Desvenlafaxine?
MediHelp rates the interaction as moderate. Clopidogrel and Desvenlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SNRIs impair platelet serotonin uptake and increase bleeding tendency, especially GI bleeding, when taken with antiplatelet drugs like clopidogrel.
How serious is the interaction between Clopidogrel and Desvenlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider gastroprotection in patients with additional risk factors.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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