Drug interactions
Clopidogrel + Enoxaparin
Severity: Moderate
Clopidogrel and Enoxaparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining enoxaparin with clopidogrel increases the risk of bleeding because one drug inhibits coagulation and the other inhibits platelets. The combination is often used intentionally in acute coronary syndromes, but bleeding events are more frequent.
What this interaction means in plain words
Clopidogrel and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Enoxaparin belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect: P2Y12 platelet inhibition plus anti-Xa and anti-thrombin III mediated anticoagulation.
What to do
Use when clinically indicated and monitor for bleeding, hemoglobin and platelets. Adjust the enoxaparin dose in renal impairment and avoid additional bleeding-risk drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Enoxaparin?
MediHelp rates the interaction as moderate. Clopidogrel and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining enoxaparin with clopidogrel increases the risk of bleeding because one drug inhibits coagulation and the other inhibits platelets. The combination is often used intentionally in acute coronary syndromes, but bleeding events are more frequent.
How serious is the interaction between Clopidogrel and Enoxaparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use when clinically indicated and monitor for bleeding, hemoglobin and platelets. Adjust the enoxaparin dose in renal impairment and avoid additional bleeding-risk drugs.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
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