Drug interactions
Clopidogrel + Fish oil
Severity: Minor
Clopidogrel and Fish oil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omega-3 fatty acids have mild antiplatelet properties, so combining them with clopidogrel might slightly increase bleeding tendency. At usual supplemental doses clinical impact appears small.
What this interaction means in plain words
Clopidogrel and Fish oil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clopidogrel belongs to Cardiovascular; Fish oil belongs to Gastrointestinal Tract.
Why it happens
Mild additive antiplatelet effect of omega-3 fatty acids.
What to do
No change usually needed; monitor for bleeding in patients taking high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clopidogrel
Other interactions of Fish oil
- Antithrombin alfa + Fish oil Moderate
- Antithrombin iii + Fish oil Moderate
- Aspirin / citric acid / sodium bicarbonate + Fish oil Moderate
- Aspirin + Fish oil Moderate
- Betrixaban + Fish oil Moderate
- Bivalirudin + Fish oil Moderate
Frequently asked questions
Can I take Clopidogrel with Fish oil?
MediHelp rates the interaction as minor. Clopidogrel and Fish oil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omega-3 fatty acids have mild antiplatelet properties, so combining them with clopidogrel might slightly increase bleeding tendency. At usual supplemental doses clinical impact appears small.
How serious is the interaction between Clopidogrel and Fish oil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change usually needed; monitor for bleeding in patients taking high doses.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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