Drug interactions
Clopidogrel + Fluvastatin
Severity: Minor
Clopidogrel and Fluvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clopidogrel and its acyl glucuronide metabolite can inhibit CYP2C8 and may modestly raise exposure to some substrates. Fluvastatin is mainly metabolized by CYP2C9, so a meaningful rise in its levels is not expected.
What this interaction means in plain words
Clopidogrel and Fluvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clopidogrel belongs to Cardiovascular; Fluvastatin belongs to Cardiovascular.
Why it happens
Possible weak CYP2C9 inhibition by clopidogrel; clinical relevance is unproven.
What to do
No dose change is needed. Monitor for statin-related muscle symptoms as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clopidogrel
Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Frequently asked questions
Can I take Clopidogrel with Fluvastatin?
MediHelp rates the interaction as minor. Clopidogrel and Fluvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clopidogrel and its acyl glucuronide metabolite can inhibit CYP2C8 and may modestly raise exposure to some substrates. Fluvastatin is mainly metabolized by CYP2C9, so a meaningful rise in its levels is not expected.
How serious is the interaction between Clopidogrel and Fluvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for statin-related muscle symptoms as usual.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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