Drug interactions
Clopidogrel + Meclofenamic acid
Severity: Major
Clopidogrel and Meclofenamic acid: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs impair platelet function, and NSAIDs also injure the gastric mucosa. Combined use increases the risk of gastrointestinal and other bleeding.
What this interaction means in plain words
Clopidogrel and Meclofenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clopidogrel belongs to Cardiovascular; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
Additive platelet inhibition from P2Y12 blockade by clopidogrel and COX-1 inhibition by the NSAID, plus NSAID mucosal injury.
What to do
Avoid regular NSAID use in patients on clopidogrel and use paracetamol where suitable. If an NSAID is necessary, add gastroprotection with a proton pump inhibitor that does not inhibit CYP2C19 strongly, and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Meclofenamic acid?
MediHelp rates the interaction as major. Clopidogrel and Meclofenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs impair platelet function, and NSAIDs also injure the gastric mucosa. Combined use increases the risk of gastrointestinal and other bleeding.
How serious is the interaction between Clopidogrel and Meclofenamic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use in patients on clopidogrel and use paracetamol where suitable. If an NSAID is necessary, add gastroprotection with a proton pump inhibitor that does not inhibit CYP2C19 strongly, and monitor for bleeding.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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