Drug interactions
Clopidogrel + Miconazole
Severity: Minor
Clopidogrel and Miconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clopidogrel is a prodrug activated by CYP2C19 and other CYPs, and miconazole inhibits CYP2C19. Systemic exposure from vaginal use is low, so the effect on platelet inhibition is likely small. Reduced activation could in theory lessen antiplatelet efficacy.
What this interaction means in plain words
Clopidogrel and Miconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clopidogrel belongs to Cardiovascular; Miconazole belongs to Anti Fungals.
Why it happens
Miconazole inhibition of CYP2C19 and CYP3A4 may reduce formation of clopidogrel's active metabolite.
What to do
No action is usually needed for a short vaginal course. In high-risk patients such as those with recent stent placement, prefer a non-azole alternative or avoid prolonged miconazole use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Miconazole
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Miconazole?
MediHelp rates the interaction as minor. Clopidogrel and Miconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clopidogrel is a prodrug activated by CYP2C19 and other CYPs, and miconazole inhibits CYP2C19. Systemic exposure from vaginal use is low, so the effect on platelet inhibition is likely small. Reduced activation could in theory lessen antiplatelet efficacy.
How serious is the interaction between Clopidogrel and Miconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is usually needed for a short vaginal course. In high-risk patients such as those with recent stent placement, prefer a non-azole alternative or avoid prolonged miconazole use.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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