Drug interactions
Clopidogrel + Nilotinib
Severity: Moderate
Clopidogrel and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and may modestly reduce formation of clopidogrel's active metabolite. The clinical effect on platelet inhibition is uncertain, and nilotinib itself prolongs QT and may cause bleeding or thrombocytopenia.
What this interaction means in plain words
Clopidogrel and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Nilotinib belongs to Oncology.
Why it happens
CYP3A4 inhibition may reduce bioactivation of clopidogrel, though CYP2C19 is the main activating enzyme.
What to do
Monitor for thrombotic events and for bleeding or thrombocytopenia with a blood count. Consider platelet function testing or an alternative antiplatelet if stent thrombosis risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clopidogrel
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Clopidogrel with Nilotinib?
MediHelp rates the interaction as moderate. Clopidogrel and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 and may modestly reduce formation of clopidogrel's active metabolite. The clinical effect on platelet inhibition is uncertain, and nilotinib itself prolongs QT and may cause bleeding or thrombocytopenia.
How serious is the interaction between Clopidogrel and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for thrombotic events and for bleeding or thrombocytopenia with a blood count. Consider platelet function testing or an alternative antiplatelet if stent thrombosis risk is high.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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