Drug interactions
Clopidogrel + Oxcarbazepine
Severity: Moderate
Clopidogrel and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may inhibit CYP2C19 and thereby reduce conversion of clopidogrel to its active form. The clinical consequence is a possible reduction in antiplatelet effect, though data are limited.
What this interaction means in plain words
Clopidogrel and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Possible CYP2C19 inhibition reduces clopidogrel bioactivation.
What to do
Consider an alternative antiepileptic in high-risk cardiovascular patients. If used together, watch for ischemic events or consider platelet function testing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clopidogrel
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Clopidogrel with Oxcarbazepine?
MediHelp rates the interaction as moderate. Clopidogrel and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may inhibit CYP2C19 and thereby reduce conversion of clopidogrel to its active form. The clinical consequence is a possible reduction in antiplatelet effect, though data are limited.
How serious is the interaction between Clopidogrel and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antiepileptic in high-risk cardiovascular patients. If used together, watch for ischemic events or consider platelet function testing.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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