Drug interactions
Clopidogrel + Tolmetin
Severity: Major
Clopidogrel and Tolmetin: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents impair platelet function, and NSAIDs also injure the gastric mucosa, so bleeding risk, especially gastrointestinal, is increased.
What this interaction means in plain words
Clopidogrel and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clopidogrel belongs to Cardiovascular; Tolmetin belongs to Musculoskeletal.
Why it happens
Additive antiplatelet effects (COX inhibition and P2Y12 blockade) plus NSAID mucosal injury.
What to do
Avoid regular NSAID use where possible and use acetaminophen instead. If needed, add gastroprotection and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Tolmetin?
MediHelp rates the interaction as major. Clopidogrel and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents impair platelet function, and NSAIDs also injure the gastric mucosa, so bleeding risk, especially gastrointestinal, is increased.
How serious is the interaction between Clopidogrel and Tolmetin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible and use acetaminophen instead. If needed, add gastroprotection and monitor for bleeding.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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