Drug interactions
Clorazepate + Dabrafenib
Severity: Moderate
Clorazepate and Dabrafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib may lower clorazepate exposure and weaken its effect. This matters most when clorazepate is used for seizure control or established anxiety treatment.
What this interaction means in plain words
Clorazepate and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Dabrafenib belongs to Oncology.
Why it happens
Dabrafenib induces CYP3A4 and speeds up metabolism of clorazepate's active metabolite.
What to do
Monitor for reduced efficacy and increase the clorazepate dose if needed. Reassess the dose after dabrafenib is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Clorazepate with Dabrafenib?
MediHelp rates the interaction as moderate. Clorazepate and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib may lower clorazepate exposure and weaken its effect. This matters most when clorazepate is used for seizure control or established anxiety treatment.
How serious is the interaction between Clorazepate and Dabrafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced efficacy and increase the clorazepate dose if needed. Reassess the dose after dabrafenib is discontinued.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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