Drug interactions
Clorazepate + Danazol
Severity: Moderate
Clorazepate and Danazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak to moderate CYP3A4 inhibitor and may raise exposure to the active metabolite of clorazepate, nordazepam. This can deepen sedation and psychomotor impairment.
What this interaction means in plain words
Clorazepate and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits CYP3A4-mediated metabolism of clorazepate and its active metabolite.
What to do
Monitor for excessive sedation, confusion and impaired coordination when starting danazol. Reduce the clorazepate dose if these effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Clorazepate with Danazol?
MediHelp rates the interaction as moderate. Clorazepate and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a weak to moderate CYP3A4 inhibitor and may raise exposure to the active metabolite of clorazepate, nordazepam. This can deepen sedation and psychomotor impairment.
How serious is the interaction between Clorazepate and Danazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, confusion and impaired coordination when starting danazol. Reduce the clorazepate dose if these effects appear.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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