Drug interactions
Clorazepate + Dextroamphetamine
Severity: Minor
Clorazepate and Dextroamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stimulants may partly mask the sedation caused by clorazepate, but they do not reverse its impairment of psychomotor performance or cognition. Patients may feel more alert than their actual performance suggests, and the net effect is unpredictable.
What this interaction means in plain words
Clorazepate and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clorazepate belongs to Central Nervous System; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic CNS effects of GABAergic depression and amphetamine-induced catecholamine release.
What to do
No dose adjustment is generally required; monitor anxiety, sleep and alertness and advise patients not to rely on perceived alertness when driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Clorazepate with Dextroamphetamine?
MediHelp rates the interaction as minor. Clorazepate and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stimulants may partly mask the sedation caused by clorazepate, but they do not reverse its impairment of psychomotor performance or cognition. Patients may feel more alert than their actual performance suggests, and the net effect is unpredictable.
How serious is the interaction between Clorazepate and Dextroamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required; monitor anxiety, sleep and alertness and advise patients not to rely on perceived alertness when driving.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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