Drug interactions
Clorazepate + Diazepam intranasal
Severity: Moderate
Clorazepate and Diazepam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are benzodiazepines, so combining them adds to sedation, respiratory depression and psychomotor impairment. Because diazepam nasal spray is used for acute seizure clusters, clorazepate use may increase oversedation after a rescue dose.
What this interaction means in plain words
Clorazepate and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive GABA-A receptor potentiation producing CNS depression.
What to do
Review the total benzodiazepine burden and monitor for oversedation and breathing problems after a rescue dose. Instruct caregivers on warning signs and when to seek emergency help.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Clorazepate with Diazepam intranasal?
MediHelp rates the interaction as moderate. Clorazepate and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are benzodiazepines, so combining them adds to sedation, respiratory depression and psychomotor impairment. Because diazepam nasal spray is used for acute seizure clusters, clorazepate use may increase oversedation after a rescue dose.
How serious is the interaction between Clorazepate and Diazepam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the total benzodiazepine burden and monitor for oversedation and breathing problems after a rescue dose. Instruct caregivers on warning signs and when to seek emergency help.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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