Drug interactions
Clorazepate + Difenoxin
Severity: Moderate
Clorazepate and Difenoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difenoxin is an opioid antidiarrheal related to diphenoxylate. With clorazepate it can add to sedation and CNS depression, especially at high doses or in vulnerable patients.
What this interaction means in plain words
Clorazepate and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Difenoxin belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression from opioid and benzodiazepine activity.
What to do
Use the lowest effective doses and warn patients about drowsiness. Avoid exceeding recommended antidiarrheal doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Difenoxin
Frequently asked questions
Can I take Clorazepate with Difenoxin?
MediHelp rates the interaction as moderate. Clorazepate and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difenoxin is an opioid antidiarrheal related to diphenoxylate. With clorazepate it can add to sedation and CNS depression, especially at high doses or in vulnerable patients.
How serious is the interaction between Clorazepate and Difenoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and warn patients about drowsiness. Avoid exceeding recommended antidiarrheal doses.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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