Drug interactions
Clorazepate + Disulfiram
Severity: Moderate
Clorazepate and Disulfiram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disulfiram inhibits hepatic oxidative metabolism of some benzodiazepines, so it may raise levels of clorazepate's active metabolite nordazepam. This can cause greater sedation and psychomotor impairment.
What this interaction means in plain words
Clorazepate and Disulfiram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Disulfiram inhibits hepatic oxidative (CYP-mediated) metabolism of the benzodiazepine.
What to do
Monitor for oversedation and reduce the clorazepate dose if needed when disulfiram is started. Lorazepam, oxazepam or temazepam, which are cleared by glucuronidation, are alternatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Clorazepate with Disulfiram?
MediHelp rates the interaction as moderate. Clorazepate and Disulfiram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Disulfiram inhibits hepatic oxidative metabolism of some benzodiazepines, so it may raise levels of clorazepate's active metabolite nordazepam. This can cause greater sedation and psychomotor impairment.
How serious is the interaction between Clorazepate and Disulfiram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and reduce the clorazepate dose if needed when disulfiram is started. Lorazepam, oxazepam or temazepam, which are cleared by glucuronidation, are alternatives.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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