Drug interactions
Clorazepate + Estazolam
Severity: Moderate
Clorazepate and Estazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are benzodiazepines, so taking them together duplicates therapy and adds to sedation, psychomotor impairment and respiratory depression. Falls and next-day impairment are particular concerns in older adults.
What this interaction means in plain words
Clorazepate and Estazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive GABA-A receptor potentiation producing CNS depression.
What to do
Avoid routine combination of two benzodiazepines and consolidate to one agent where possible. If both are needed, use the lowest doses and monitor for oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Clorazepate with Estazolam?
MediHelp rates the interaction as moderate. Clorazepate and Estazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are benzodiazepines, so taking them together duplicates therapy and adds to sedation, psychomotor impairment and respiratory depression. Falls and next-day impairment are particular concerns in older adults.
How serious is the interaction between Clorazepate and Estazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination of two benzodiazepines and consolidate to one agent where possible. If both are needed, use the lowest doses and monitor for oversedation.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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