Drug interactions
Clorazepate + Gabapentin
Severity: Moderate
Clorazepate and Gabapentin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a benzodiazepine with gabapentin increases sedation, dizziness and risk of respiratory depression. Risk is greater in older adults, those with COPD, and with concomitant opioids.
What this interaction means in plain words
Clorazepate and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Gabapentin belongs to Central Nervous System.
Why it happens
Additive central nervous system and respiratory depression.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression, especially during dose increases.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Gabapentin
Frequently asked questions
Can I take Clorazepate with Gabapentin?
MediHelp rates the interaction as moderate. Clorazepate and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a benzodiazepine with gabapentin increases sedation, dizziness and risk of respiratory depression. Risk is greater in older adults, those with COPD, and with concomitant opioids.
How serious is the interaction between Clorazepate and Gabapentin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression, especially during dose increases.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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