Drug interactions
Clorazepate + Loxapine inhaled
Severity: Moderate
Clorazepate and Loxapine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled loxapine is contraindicated or cautioned with benzodiazepines because of additive sedation and respiratory effects, and it can cause bronchospasm. Combined use may heighten drowsiness and impair respiratory drive.
What this interaction means in plain words
Clorazepate and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression from dopamine/serotonin antagonism and GABA-A potentiation.
What to do
Monitor for sedation and respiratory depression after loxapine inhalation, and use only in a supervised setting with bronchodilator available. Reduce doses if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Clorazepate with Loxapine inhaled?
MediHelp rates the interaction as moderate. Clorazepate and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled loxapine is contraindicated or cautioned with benzodiazepines because of additive sedation and respiratory effects, and it can cause bronchospasm. Combined use may heighten drowsiness and impair respiratory drive.
How serious is the interaction between Clorazepate and Loxapine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression after loxapine inhalation, and use only in a supervised setting with bronchodilator available. Reduce doses if oversedation occurs.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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