Drug interactions
Clorazepate + Marijuana
Severity: Moderate
Clorazepate and Marijuana: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis has sedative and psychomotor-impairing effects that add to those of benzodiazepines. The combination may impair driving, memory, and coordination.
What this interaction means in plain words
Clorazepate and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through cannabinoid receptor and GABAergic effects.
What to do
Advise patients to avoid cannabis while taking clorazepate, or at least avoid driving and hazardous activities. Monitor for oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Clorazepate with Marijuana?
MediHelp rates the interaction as moderate. Clorazepate and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis has sedative and psychomotor-impairing effects that add to those of benzodiazepines. The combination may impair driving, memory, and coordination.
How serious is the interaction between Clorazepate and Marijuana?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid cannabis while taking clorazepate, or at least avoid driving and hazardous activities. Monitor for oversedation.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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