Drug interactions
Clorazepate + Nafcillin
Severity: Minor
Clorazepate and Nafcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is an inducer of CYP3A4 and may lower concentrations of clorazepate's active metabolite, reducing its effect. Clinical relevance is mostly during prolonged nafcillin courses.
What this interaction means in plain words
Clorazepate and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP3A4 increasing metabolism of nordiazepam.
What to do
Monitor for reduced anxiolytic or anticonvulsant effect during nafcillin therapy and adjust the clorazepate dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Clorazepate with Nafcillin?
MediHelp rates the interaction as minor. Clorazepate and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin is an inducer of CYP3A4 and may lower concentrations of clorazepate's active metabolite, reducing its effect. Clinical relevance is mostly during prolonged nafcillin courses.
How serious is the interaction between Clorazepate and Nafcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced anxiolytic or anticonvulsant effect during nafcillin therapy and adjust the clorazepate dose if needed.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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