Drug interactions
Clorazepate + Olanzapine / samidorphan
Severity: Moderate
Clorazepate and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clorazepate and olanzapine produce additive central nervous system depression, with more sedation, dizziness and psychomotor impairment. Orthostatic hypotension may also be amplified, raising the risk of falls, especially in older patients.
What this interaction means in plain words
Clorazepate and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic CNS depression and hypotensive effects from GABA-A potentiation by the benzodiazepine and receptor antagonism by olanzapine.
What to do
Monitor for excessive sedation and orthostatic hypotension, particularly at initiation and dose changes. Use the lowest effective benzodiazepine dose and counsel patients to rise slowly and avoid driving or alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clorazepate and Olanzapine / samidorphan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Clorazepate with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Clorazepate and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clorazepate and olanzapine produce additive central nervous system depression, with more sedation, dizziness and psychomotor impairment. Orthostatic hypotension may also be amplified, raising the risk of falls, especially in older patients.
How serious is the interaction between Clorazepate and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and orthostatic hypotension, particularly at initiation and dose changes. Use the lowest effective benzodiazepine dose and counsel patients to rise slowly and avoid driving or alcohol.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
