Drug interactions
Clorazepate + Olanzapine
Severity: Moderate
Clorazepate and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sedating, and together they increase drowsiness, orthostatic hypotension and psychomotor impairment. Parenteral olanzapine with benzodiazepines has been linked to excess sedation and cardiorespiratory depression.
What this interaction means in plain words
Clorazepate and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and olanzapine's antihistaminic and antiadrenergic effects.
What to do
Monitor sedation, blood pressure and respiratory status, especially after starting or raising doses. Avoid giving intramuscular olanzapine close to parenteral benzodiazepines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Olanzapine
Frequently asked questions
Can I take Clorazepate with Olanzapine?
MediHelp rates the interaction as moderate. Clorazepate and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are sedating, and together they increase drowsiness, orthostatic hypotension and psychomotor impairment. Parenteral olanzapine with benzodiazepines has been linked to excess sedation and cardiorespiratory depression.
How serious is the interaction between Clorazepate and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and respiratory status, especially after starting or raising doses. Avoid giving intramuscular olanzapine close to parenteral benzodiazepines.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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