Drug interactions
Clorazepate + Orphenadrine
Severity: Moderate
Clorazepate and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine has sedating and anticholinergic effects that add to the CNS depression caused by clorazepate. This can produce drowsiness, confusion and impaired coordination, particularly in older adults.
What this interaction means in plain words
Clorazepate and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation and central anticholinergic activity.
What to do
Monitor for sedation, confusion and falls, and reduce the dose of one or both agents if impairment occurs. Advise against driving and alcohol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Clorazepate with Orphenadrine?
MediHelp rates the interaction as moderate. Clorazepate and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine has sedating and anticholinergic effects that add to the CNS depression caused by clorazepate. This can produce drowsiness, confusion and impaired coordination, particularly in older adults.
How serious is the interaction between Clorazepate and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, confusion and falls, and reduce the dose of one or both agents if impairment occurs. Advise against driving and alcohol use.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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