Drug interactions
Clorazepate + Pimozide
Severity: Moderate
Clorazepate and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, so combining them increases sedation and impairment. Pimozide additionally carries a risk of QT prolongation, which makes safe use of sedatives and other CNS-active drugs more important to monitor.
What this interaction means in plain words
Clorazepate and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation and dopamine D2 antagonism.
What to do
Monitor sedation and coordination, and use the lowest effective doses. Keep electrolytes normal and follow ECG monitoring guidance for pimozide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Clorazepate with Pimozide?
MediHelp rates the interaction as moderate. Clorazepate and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, so combining them increases sedation and impairment. Pimozide additionally carries a risk of QT prolongation, which makes safe use of sedatives and other CNS-active drugs more important to monitor.
How serious is the interaction between Clorazepate and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and coordination, and use the lowest effective doses. Keep electrolytes normal and follow ECG monitoring guidance for pimozide.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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